27
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T60003 | AC1-IN-1 | Adenylyl cyclase | |
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM). | |||
T5513 | RO-3 | P2X Receptor | |
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor | |||
T6039 | TAK-285 | TAK285,TAK 285 | EGFR , MEK , HER , Aurora Kinase |
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1. | |||
T0682 | Lamivudine | GR109714X,BCH-189 | HIV Protease , Reverse Transcriptase |
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. | |||
T24047 | Etilevodopa hydrochloride | Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester | Others , Dopamine Receptor , Drug Metabolite |
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration. | |||
T0688 | Ganciclovir | BW 759,RS-21592,2'-Nor-2'-deoxyguanosine | Nucleoside Antimetabolite/Analog , Others , Antibiotic , Antifection , HSV |
Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegaloviru... | |||
T22337 | Ganciclovir sodium | RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium | Nucleoside Antimetabolite/Analog , Others , Antifection , HSV |
Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1). | |||
T12679 | (Rac)-VU 6008667 | Others , AChR | |
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50 of 1.8 μM and pIC50 of 5.75, has high CNS penetration. | |||
T25124 | AZ599 | AZ-599,AZ 599 | |
AZ599 is a full agonist of CB1 with good solubility and low CNS penetration. | |||
T26722 | AZD7268 | AZD-7268,AZD 7268 | |
AZD7268 is a potent, selective, reversible, and orally bioavailable agonist of δ-opioid receptor with CNS penetration. | |||
T28067 | ML372 | ML 372,ML-372 | |
ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration. | |||
T29142 | VU6001966 | VU 6001966,VU-6001966 | |
VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration. | |||
T17241 | Auglurant | VU0424238 | Others |
Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration. | |||
T27474 | GSK-345931A | GSK-345931A free acid,GSK 345931A free acid,GSK 345931A | |
GSK-345931A, an EP(1) receptor antagonist, shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain. | |||
T35081 | VU0486321 | VU 0486321,VU-0486321 | |
VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02). | |||
T29151 | WAY267464 HCl | WAY267464,WAY-267464,WAY 267,464 dihydrochloride,WAY-267,464 dihydrochloride,WAY 267464 dihydrochloride,WAY 267464 | |
WAY267464 is a nonpeptide small-molecule OT agonists with anxiolytic activity. WAY267464 may be used for modulation of potency, selectivity over the structurally similar vasopressin receptors, CNS penetration, and oral b... | |||
T25819 | ML350 | SR-2311,SR 2311,SR2311,ML-350,ML 350 | |
ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting ... | |||
T36644 | Rezivertinib | ||
Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI) with potent activity against both common activation EGFR and resistance T790M mutations... | |||
T69780 | VU6007477 | ||
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp,uu = 0.32;... | |||
T39343 | MW-150 hydrochloride | MW01-18-150SRM hydrochloride,MW-150 hydrochloride | |
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-... | |||
T61210 | R-PSOP | ||
R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous syste... | |||
T69850 | SHR0687 | ||
SHR0687 is a Highly Potent KOR Agonist. SHR0687 showed excellent selectivity over other opioid receptors, such as MOR and DOR. In addition, SHR0687 displayed favorable PK profiles across species, as well as robust in viv... | |||
T68356 | AM-3189 | ||
AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displa... | |||
T73176 | LRRK2-IN-7 | ||
LRRK2-IN-7 is a potent LRRK2 kinase inhibitor that demonstrates high selectivity and central nervous system (CNS) penetration, possessing an IC50 value of 0.9 nM. It exhibits more than 1000-fold selectivity against a bro... | |||
T33950 | PF-06767832 | PF-6767832,PF6767832,PF 6767832,PF 06767832 | |
PF-06767832 is a high quality M1 selective PAM (M1 PAM EC50 = 60 nM; M2-M5 PAM EC50 > 10 microM; CNS MPO = 4.9). PF-06767832 has well aligned physicochemical properties, good brain penetration and pharmacokinetic prop... | |||
T21750 | A 784168 | ||
A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, an... | |||
T71577 | KOS-1584 | ||
KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which m... |